Human umbilical cord mesenchymal stem cell promotes angiogenesis via integrin β1/ERK1/2/HIF-1α/VEGF-A signaling pathway for off-the-shelf breast tissue engineering.
Mian WuLifeng ChenYuhan QiHai CiShan MouJie YangQiaoyu YuanWeiqi YaoZhenxing WangJiaming SunPublished in: Stem cell research & therapy (2022)
These results demonstrate that allogeneic hUCMSCs promote the regeneration of adipose tissue and can be used to construct a tissue engineered breast.
Keyphrases
- umbilical cord
- endothelial cells
- mesenchymal stem cells
- tissue engineering
- signaling pathway
- adipose tissue
- bone marrow
- pi k akt
- vascular endothelial growth factor
- stem cells
- stem cell transplantation
- epithelial mesenchymal transition
- cell proliferation
- cell therapy
- insulin resistance
- wound healing
- high fat diet
- induced apoptosis
- type diabetes
- induced pluripotent stem cells
- metabolic syndrome
- pluripotent stem cells
- low dose
- cell migration