Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination.
Raghav SundarDrolaiz Hw LiuGordon G A HutchinsHayley L SlaneyArnaldo N S SilvaJan OostingJeremy D HaydenLindsay C HewittCedric Chuan Young NgAmrita MangalvedhekarSarah B NgIain Bh TanPatrick Boon-Ooi TanHeike I GrabschPublished in: Gut (2020)
In GC, regional lymph node metastases are likely to originate from deeper subregions of the primary tumour. Future clinical trials of novel targeted therapies must consider assessment of deeper subregions of the primary tumour and/or metastases as several therapeutically relevant genes are only mutated, overexpressed or amplified in these regions.