Caspase-3-Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma.

Etienne Ho Kit MokCarmen Oi Ning LeungLei ZhouMartina Mang Leng LeiHoi Wing LeungMan Tong Tin-Lok WongEunice Yuen Ting LauIrene Oi Lin NgJin DingJing-Ping Yun Jun YuHui Lian ZhuChi Ho LinDan LindholmKit Sum LeungJonathan D CybulskiDavid M BakerStephianie Ma Terence Kin-Wah Lee

Published in: Cancer research (2022)

This study finds that cholesterol biosynthesis supports the expansion of cancer stem cell populations to drive resistance to tyrosine kinase inhibitor therapy in hepatocellular carcinoma, identifying potential therapeutic approaches for improving cancer treatment.

Keyphrases

cancer stem cells
low density lipoprotein
cell death
high glucose
diabetic rats
cell wall
stem cells
oxidative stress
drug induced
endothelial cells
signaling pathway
endoplasmic reticulum stress