Metabolic reprogramming of poly(morpho)nuclear giant cells determines glioblastoma recovery from doxorubicin-induced stress.
Maciej PudełekDamian RyszawyKatarzyna PiwowarczykSławomir LasotaZbigniew MadejaSylwia Kędracka-KrokJarosław CzyżPublished in: Journal of translational medicine (2024)
These data demonstrate the cooperative pattern of GBM recovery from DOX-induced stress and the crucial role of metabolic reprogramming of PGCs in this process. Metabolic reprogramming enhances the efficiency of self-defense systems and increases the DOX retention capacity of PGCs, potentially reducing DOX bioavailability in the proximity of SECs. Consequently, the modulation of PGC metabolism is highlighted as a potential target for intervention in glioblastoma treatment.
Keyphrases
- high glucose
- diabetic rats
- randomized controlled trial
- induced apoptosis
- drug induced
- drug delivery
- skeletal muscle
- stress induced
- machine learning
- oxidative stress
- electronic health record
- cell cycle arrest
- climate change
- heat stress
- signaling pathway
- replacement therapy
- data analysis
- endoplasmic reticulum stress
- artificial intelligence
- smoking cessation