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Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001.

Lynda M VroomanTraci M BlonquistKristen E StevensonJeffrey G SupkoSarah K HuntSarah M CronholmVictoria KochSamantha Kay-GreenUma H AthaleLuis A ClavellPeter D ColeMarian H HarrisKara M KellyCaroline LaverdiereJean-Marie LeclercBruno MichonAndrew E PlaceMarshall A SchorinJennifer J G WelchDonna S NeubergStephen E SallanLewis B Silverman
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Every 3-week calaspargase had similar nadir SAA, toxicity, and survival outcomes compared with every 2-week pegaspargase. The high nadir SAA observed for both preparations suggest dosing strategies can be further optimized.
Keyphrases
  • acute lymphoblastic leukemia
  • oxidative stress
  • placebo controlled
  • randomized controlled trial
  • oxide nanoparticles
  • early life
  • childhood cancer
  • double blind