Estrogen concentration and estrogen receptor-β expression in postmenopausal colon cancer considering patient/tumor background.

Naoko HonmaTomio AraiYoko MatsudaYosuke FukunagaYuri Akishima-FukasawaNoriko YamamotoHiroshi KawachiYuichi IshikawaKengo TakeuchiTetuo Mikami

Published in: Journal of cancer research and clinical oncology (2022)

The present results suggest that estrogens do not suppress, but rather promote, R-Ca ≥ 70, Med/Muc, or deficient-MMR tumors, whereas estrogens suppress L-Ca < 70, non-Med/Muc, or proficient-MMR tumors, confirming the difference in pathobiological role of estrogens in postmenopausal colon cancer according to the patients' age and tumor background. This may at least partly explain the controversy regarding the association between estrogens and CRC.

Keyphrases

estrogen receptor
end stage renal disease
ejection fraction
newly diagnosed
bone mineral density
poor prognosis
prognostic factors
protein kinase
binding protein