Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy.
Fengying WuTao JiangGongyan ChenYunchao HuangJianying ZhouLizhu LinJifeng FengZhehai WangYongqian ShuJianhua ShiYi HuQiming WangYing ChengJianhua ChenXiaoyan LinYongsheng WangJianan HuangJiuwei CuiLejie CaoYunpeng LiuYiping ZhangYueyin PanJun ZhaoLiPing WangJianhua ChangQun ChenXiu-Bao RenWei ZhangYun FanZhiyong HeJian FangKangsheng GuXiaorong DongTao ZhangWei ShiJianjun ZouXuejuan BaiShengxiang RenCaicun Zhounull nullPublished in: Cancer communications (London, England) (2022)
Tumor immune microenvironmental marker expression, especially CD8/PD-L1 or CD68/PD-L1 co-expression, was associated with the efficacy of PD-1 blockade plus chemotherapy as first-line treatment in patients with advanced NSCLC.