Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field.
Marília Berlofa VisacriAline de Souza NicolettiEder de Carvalho PincinatoPía LorenNicolás SaavedraKathleen SaavedraLuis A SalazarPatricia MorielPublished in: Biomarkers in medicine (2021)
Aim: miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. Materials & methods: A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer. Results: Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction. Conclusion: This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.
Keyphrases
- sars cov
- coronavirus disease
- current status
- cell proliferation
- induced apoptosis
- respiratory syndrome coronavirus
- long non coding rna
- immune response
- oxidative stress
- long noncoding rna
- cell cycle arrest
- systematic review
- signaling pathway
- case control
- randomized controlled trial
- cell death
- big data
- dendritic cells
- machine learning
- endoplasmic reticulum stress
- deep learning
- electronic health record