Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer.

Joshua K Sabari Vamsidhar Velcheti Kazuhide Shimizu Matthew R StricklandRebecca S HeistMohini SinghNaema NayyarAnita Giobbie-Hurder Subba R Digumarthy Justin F GainorAnant P RajanEdwin Nieblas-Bedolla Aaron C Burns Jill HallinPeter OlsonJames G ChristensenSylvia C Kurz Priscilla Kaliopi Brastianos Hiroaki Wakimoto

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

These data support further development of adagrasib in patients with KRASG12C-mutant NSCLC with untreated BM. See related commentary by Kommalapati and Mansfield, p. 3179.

Keyphrases

brain metastases
small cell lung cancer
electronic health record
big data
wild type
data analysis
machine learning
cell therapy