Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model.

Hyewon ParkHyelim ParkDasom MunJiyoung KangHyoeun KimMichael KimShanyu CuiSeung Hyun LeeBoyoung Joung

Published in: Yonsei medical journal (2018)

EV(HM) reduced IR injury by suppressing GSK3β expression via miRNA-26a and increased Cx43 expression. These findings suggest that the beneficial effect of EVHM is related with Wnt signaling pathway.

Keyphrases

signaling pathway
poor prognosis
mesenchymal stem cells
pi k akt
ischemia reperfusion injury
binding protein
stem cells
endothelial cells
cell proliferation
bone marrow
epithelial mesenchymal transition
cell therapy