Association of PON1 gene promoter DNA methylation with the risk of Clopidogrel resistance in patients with coronary artery disease.

Jia SuJiyi LiQinglin YuXiaofeng XuJingqiao WangJin YangXiaojing LiXiaomin Chen

Published in: Journal of clinical laboratory analysis (2019)

The DNA methylation of CpG4 in the PON1 promoter would lead to a low expression of PON1 mRNA, which might induce clopidogrel resistance in the patients with dyslipidemia, and the number of stents might be a risk for CR.

Keyphrases

dna methylation
genome wide
acute coronary syndrome
gene expression
copy number
percutaneous coronary intervention
antiplatelet therapy
poor prognosis
binding protein
transcription factor
coronary artery disease
genome wide identification