N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats.

Wating SuYuan ZhangQiongxia ZhangJinjin XuLiying ZhanQiqi ZhuQingquan LianHuimin LiuZhong-Yuan XiaZheng-Yuan XiaShaoqing Lei

Published in: Cardiovascular diabetology (2016)

Hyperglycemia-induced inhibition of eNOS activity might be consequences of caveolae dysfunction and reduced Cav-3 expression. Antioxidant NAC attenuated myocardial dysfunction and myocardial I/R injury by improving Cav-3/eNOS signaling.

Keyphrases

diabetic rats
oxidative stress
left ventricular
nitric oxide synthase
pi k akt
endothelial cells
poor prognosis
transcription factor
nitric oxide
heart failure
high glucose