Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia.

Oliver M MooreYuriana Aguilar-SanchezSatadru K LahiriMohit M HulsurkarJ Alberto Navarro-GarciaTarah A WordJoshua A KeefeDean BaraziElda M MunivezCharles T MooreVaidya ParthasarathyJaysón DavidsonWilliam R LagorSo Hyun ParkGang BaoChristina Y MiyakeXander H T Wehrens

Published in: The journal of cardiovascular aging (2024)

allele, preventing lethal arrhythmias while preserving normal cardiac function in the R176Q/+ mouse model of CPVT.

Keyphrases

genome editing
crispr cas
mouse model
left ventricular
congenital heart disease
atrial fibrillation