High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome.

Nithya KrishnamurthyDaisuke NishizakiScott M LippmanHirotaka MiyashitaMary K NeslineSarabjot PablaJeffrey M ConroyPaul DePietroShumei KatoRazelle Kurzrock

Published in: Therapeutic advances in medical oncology (2024)

High CTLA-4, especially when combined with high PD-L1 transcript expression, was a significant positive predictive biomarker for better outcomes (PFS and OS) in patients on immunotherapy.

Keyphrases

poor prognosis
binding protein
type diabetes
rna seq
long non coding rna
prognostic factors
metabolic syndrome
adipose tissue
single cell
chronic kidney disease
insulin resistance