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High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome.

Nithya KrishnamurthyDaisuke NishizakiScott M LippmanHirotaka MiyashitaMary K NeslineSarabjot PablaJeffrey M ConroyPaul DePietroShumei KatoRazelle Kurzrock
Published in: Therapeutic advances in medical oncology (2024)
High CTLA-4, especially when combined with high PD-L1 transcript expression, was a significant positive predictive biomarker for better outcomes (PFS and OS) in patients on immunotherapy.
Keyphrases
  • poor prognosis
  • binding protein
  • type diabetes
  • rna seq
  • long non coding rna
  • prognostic factors
  • metabolic syndrome
  • adipose tissue
  • single cell
  • chronic kidney disease
  • insulin resistance