Prospective analysis of circulating biomarkers and ovarian cancer risk in the UK Biobank.

Naoko Sasamoto Cassandra A Hathaway Mary K Townsend Kathryn L Terry Britton Trabert Shelley T Tworoger

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2024)

These results suggest metabolism of glucose/amino acid and insulin/IGF-1 signaling pathway may be contributing to ovarian carcinogenesis. Further research is needed to replicate our findings and elucidate how systemic changes in metabolism impact ovarian carcinogenesis.

Keyphrases

signaling pathway
amino acid
pi k akt
type diabetes
epithelial mesenchymal transition
cross sectional
blood glucose
induced apoptosis
glycemic control
cell proliferation
blood pressure
insulin resistance
adipose tissue
endoplasmic reticulum stress