The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling.
Haizhu GaoZhongxin LiLijun GanXueying ChenPublished in: Journal of cardiovascular translational research (2024)
Rehabilitation exercise is a crucial non-pharmacological intervention for the secondary prevention and treatment of cardiovascular diseases, effectively ameliorating cardiac remodeling in patients. Exercise training can mitigate cardiomyocyte apoptosis, reduce extracellular matrix deposition and fibrosis, promote angiogenesis, and regulate inflammatory response to improve cardiac remodeling. This article presents a comprehensive review of recent research progress, summarizing the pivotal role and underlying mechanism of rehabilitation exercise in improving cardiac remodeling and providing valuable insights for devising effective rehabilitation treatment programs. Graphical Abstract.
Keyphrases
- extracellular matrix
- left ventricular
- inflammatory response
- high intensity
- physical activity
- cardiovascular disease
- end stage renal disease
- randomized controlled trial
- newly diagnosed
- resistance training
- chronic kidney disease
- oxidative stress
- public health
- prognostic factors
- heart failure
- type diabetes
- metabolic syndrome
- angiotensin ii
- risk assessment
- signaling pathway
- combination therapy
- lps induced
- cardiovascular events
- wound healing
- liver fibrosis