Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes.
Paola MaffiTorbjörn LundgrenGunnar TufvesonEhab RafaelJames A M ShawAaron LiewFrantisek SaudekPiotr WitkowskiKarolina GolabFederico BertuzziBengt GustafssonLuisa DaffonchioPier Adelchi RuffiniLorenzo PiemontiLorenzo PiemontiPublished in: Diabetes care (2020)
In this first double-blind randomized trial, islet transplantation data obtained with reparixin do not support a role of CXCR1/2 inhibition in preventing islet inflammation-mediated damage.