Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures.

Ingrid JurickovaErin BonkowskiElizabeth AngermanElizabeth NovakAlex HuronGrayce AkersKentaro IwasawaTzipi BraunRotem HadarMaria HookerSarah HanDavid J CutlerDavid T OkouSubra KugathasanAnil JeggaJames WellsTakanori TakebeKevin P MollenYael HabermanLee A Denson

Published in: Inflammatory bowel diseases (2022)

ETYA regulates ECM genes implicated in strictures and suppresses collagen content and tissue stiffness in an HIO model. HIOs provide a platform to test personalized therapeutics, including small molecules prioritized by perturbagen analysis.

Keyphrases

extracellular matrix
endothelial cells
signaling pathway
small molecule
high throughput
gene expression
bioinformatics analysis
single cell