Contrasting genomic profiles from metastatic sites, primary tumors, and liquid biopsies of advanced prostate cancer.

Andrea NecchiVito CucchiaraPetros D GrivasGennady BratslavskyJoseph JacobPhilippe E SpiessEthan S SokolJonathan Keith KillianDouglas LinShakti RamkissoonRichard S P HuangRussell W MadisonJeffrey M VenstromAlexa B SchrockNatalie DanzigerBrennan DeckerOle GjoerupRyon P GrafGeoffrey R OxnardHanna TukachinskyJeffrey S Ross

Published in: Cancer (2021)

CGP of PTs, MET sites, and ctDNA in PC exhibited differences most likely associated with tumor progression, clonal evolution, and exposure to systemic therapies; ctDNA can also capture a broad range of potential therapeutic opportunities for patients with PC.

Keyphrases

prostate cancer
circulating tumor
radical prostatectomy
squamous cell carcinoma
small cell lung cancer
poor prognosis
tyrosine kinase
ionic liquid
ultrasound guided
copy number
circulating tumor cells