Neurosteroid [3α,5α]3-hydroxypregnan-20-one inhibition of chemokine monocyte chemoattractant protein-1 in alcohol-preferring rat brain neurons, microglia, and astroglia.

Samantha Lucenell ChéryTodd K O'BuckleyGiorgia BoeroIrina BalanA Leslie Morrow

Published in: Alcohol, clinical & experimental research (2024)

These data suggest that 3α,5α-THP inhibits neuronal MCP-1 expression and decreases the proliferation of microglia in P rats. These results increase our understanding of potential mechanisms for 3α,5α-THP modulation of ethanol consumption.

Keyphrases

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alcohol consumption
cerebral ischemia
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brain injury
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