Evolvability of cancer-associated genes under APOBEC3A/B selection.

in the human genome. Interestingly, the distribution in the genome of a bat that has many APOBEC genes was similar. In contrast, when analyzing the subset of cancer-associated genes the distribution is bimodal with many genes appearing to susceptible to APOBEC activity.Analysis of orthologs of human genes and other species showed a wide range in the extent to which APOBEC affects genes having the same function.The bimodal distribution of susceptibility to APOBEC drives greater heterogeneity in simulated clonal evolution of cancer.