Impact of obesity and white adipose tissue inflammation on the omental microenvironment in endometrial cancer.
Lea A MoukarzelLorenzo FerrandoAnthe StylianouStephanie LobaughMichelle WuSilvana Pedra NobreAlexia IasonosGabriele ZoppoliDilip D GiriNadeem R Abu-RustumVance A BroachNeil M IyengarJorge S Reis-FilhoVicky MakkerPublished in: Cancer (2022)
WAT inflammation is associated with metabolic syndrome, obesity, and inflammatory markers, as well as increased expression of proinflammatory and proneoplastic genes.
Keyphrases
- metabolic syndrome
- insulin resistance
- endometrial cancer
- adipose tissue
- oxidative stress
- high fat diet induced
- weight loss
- high fat diet
- type diabetes
- poor prognosis
- weight gain
- uric acid
- stem cells
- skeletal muscle
- cardiovascular risk factors
- genome wide
- transcription factor
- cardiovascular disease
- gene expression
- dna methylation