Pharmacological and genetic characterisation of the canine P2X4 receptor.

Reece Andrew SophocleousTracey BergRocio K Finol-UrdanetaVanessa SluyterShikara KeshiyaLachlan BellStephen J CurtisBelinda L CurtisAine SeaversRachael BartlettMark DowtonLeanne StokesLezanne Ooi Ronald Sluyter

Published in: British journal of pharmacology (2020)

P2X4 receptors are highly conserved across dog pedigrees and display expression patterns and pharmacological profiles similar to human receptors, supporting validation and use of therapeutic agents for P2X4 receptor-related disease onset and management in dogs and humans.

Keyphrases

endothelial cells
poor prognosis
binding protein
transcription factor
genome wide
gene expression