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Water-Mediated On-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions.

Masahiro OkadaShi Chao XieYusuke KobayashiHiroaki YanagimotoDaisuke TsugawaMasaru TanakaTakayoshi NakanoTakumi FukumotoTakuya Matsumoto
Published in: Advanced healthcare materials (2024)
Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.
Keyphrases
  • solid state
  • tissue engineering
  • laparoscopic surgery
  • gene expression
  • metal organic framework
  • healthcare
  • highly efficient
  • lactic acid
  • ionic liquid
  • risk assessment
  • human health
  • drug delivery