Unraveling the Connection: Extracellular Vesicles and Non-Small Cell Lung Cancer.
Jiankang WuYan ChenPublished in: International journal of nanomedicine (2024)
Extracellular vesicles (EVs) are nanoscale lipid bilayer vesicles released during cell activation, cellular damage, or apoptosis. They carry nucleic acids, proteins, and lipids facilitating intercellular communication and activate signaling pathways in target cells. In non-small cell lung cancer (NSCLC), EVs may contribute to tumor growth and metastasis by modulating immune responses, facilitating epithelial-mesenchymal transition, and promoting angiogenesis, while potentially contributing to resistance to chemotherapy drugs. EVs in liquid biopsies serve as non-invasive biomarkers for early cancer detection and diagnosis. Due to their small size, inherent molecular transport properties, and excellent biocompatibility, EVs also act as natural drug delivery vehicles in NSCLC therapy.
Keyphrases
- epithelial mesenchymal transition
- signaling pathway
- cell cycle arrest
- induced apoptosis
- small cell lung cancer
- drug delivery
- pi k akt
- oxidative stress
- immune response
- endoplasmic reticulum stress
- advanced non small cell lung cancer
- cell death
- papillary thyroid
- cell therapy
- transforming growth factor
- single cell
- fatty acid
- endothelial cells
- locally advanced
- squamous cell
- squamous cell carcinoma
- single molecule
- high resolution
- cancer therapy
- label free
- loop mediated isothermal amplification
- lymph node metastasis
- real time pcr