In vitro collagen biomarkers in mechanically stimulated human tendon cells: a systematic review.
Kipling SquierRouhollah MousavizadehFaraz DamjiCharlotte BeckMichael HuntAlexander ScottPublished in: Connective tissue research (2024)
A limited number of studies, unfortunately characterized by a definite high risk of bias, suggest that in vitro mechanical stimulation primarily increases type I collagen synthesis by human tendon cells. Findings from this systematic review provide researchers and clinicians with biological evidence concerning the possible beneficial influence of exercise and loading on cellular-level tendon adaptation.
Keyphrases
- induced apoptosis
- systematic review
- endothelial cells
- anterior cruciate ligament reconstruction
- induced pluripotent stem cells
- rotator cuff
- physical activity
- oxidative stress
- endoplasmic reticulum stress
- high intensity
- meta analyses
- randomized controlled trial
- palliative care
- signaling pathway
- cell death
- wound healing