TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy.

Yu HuangZhiyong XiongJianjun WangYafen GaoQi CaoDecai WangJian ShiZhixian ChenXiong Yang

Published in: Journal of translational medicine (2024)

Our research reveals a completely new pathway, HIF-2α/hsa-miR-7-5p/TBC1D5 pathway affects ccRCC progression and lipid metabolism by regulating autophagy.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
endothelial cells
poor prognosis