Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review.
Lan LiuMeizuo ZhongXuan ZhouFanhua KangYong LongJunfeng LiPublished in: OncoTargets and therapy (2024)
Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive malignancy. Most patients are diagnosed at a late stage with poor prognosis. The treatment usually includes combined intensive chemotherapy, cytoreductive surgery, radiotherapy, and targeted therapy. Due to the low incidence rate and dismal survival, there is currently a lack of case reports on DSRCT with concurrent leukemia. We report a case of a young patient who achieved disease stabilization for 14 months after receiving 6 cycles of chemotherapy and whole abdominal radiation therapy (WART), followed by consolidation treatment with anlotinib. However, the treatment was terminated due to the development of Acute Myeloid Leukemia-M5 (AML-M5). Multimodal therapy may provide a survival benefit for rare tumors that lack standard treatment. However, intensive chemotherapy and extensive radiotherapy carry a risk of inducing secondary malignancies. This is the first reported case of concurrent DSRCT and AML-M5 with short intervals between onset.
Keyphrases
- acute myeloid leukemia
- radiation therapy
- locally advanced
- poor prognosis
- squamous cell carcinoma
- end stage renal disease
- minimally invasive
- long non coding rna
- case report
- allogeneic hematopoietic stem cell transplantation
- radiation induced
- peritoneal dialysis
- coronary artery disease
- cell therapy
- smoking cessation
- atrial fibrillation
- patient reported outcomes
- coronary artery bypass