Exosomes miR-92a-3p from human exfoliated deciduous teeth inhibits periodontitis progression via the KLF4/PI3K/AKT pathway.
Tianliang YuNa MiYingtao SongWeili XiePublished in: Journal of periodontal research (2024)
Taken together, our finding revealed that exosomal miR-92a-3p derived from SHED contributed to the alleviation of periodontitis development and progression through inactivating the KLF4/PI3K/AKT signaling pathway, which may provide a potential target for the treatment of periodontitis.
Keyphrases
- pi k akt
- signaling pathway
- cell proliferation
- cell cycle arrest
- endothelial cells
- transcription factor
- induced apoptosis
- mesenchymal stem cells
- epithelial mesenchymal transition
- stem cells
- induced pluripotent stem cells
- pluripotent stem cells
- cell death
- combination therapy
- oxidative stress
- climate change
- human health
- replacement therapy