ALLIANCE A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer.

Janet AlvarezQ ShiA DasariJ Garcia-AguilarH SanoffT J GeorgeT S HongG YothersP A PhilipG D NelsonT Al BaghdadiO AleseW ZambareD M OmerF S VerheijJ BuckleyH WilliamsM GeorgeR GarciaE M O'ReillyJ A MeyerhardtA ShergillN HorvatP B RomesserW A HallJ J Smith

Published in: medRxiv : the preprint server for health sciences (2024)

Clinicaltrials.gov ID: NCT05610163 ; Support includes U10CA180868 (NRG) and U10CA180888 (SWOG).

Keyphrases

phase ii
locally advanced
rectal cancer
clinical trial
free survival
open label
neoadjuvant chemotherapy
phase iii
phase ii study
squamous cell carcinoma
radiation therapy
double blind
placebo controlled
study protocol
protein kinase
randomized controlled trial
lymph node