Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial.

Daniel RodriguezChris JonesPascale VarletAlan MackayDaniel WarrenMonika Warmuth-MetzEsther Sánchez AliagaRaphael CalmonDarren R HargraveAdela CañeteMaura Massimino Amedeo A AziziMarie-Cécile Le DeleyFrank SaranRaphael F RousseauGudrun ZahlmannJosep GarciaGilles VassalJacques Grill Paul S Morgan Timothy Jaspan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

This study has shown that the poor outcome of midline tumors (compared with cerebral) may be related to (1) lesser surgical resection, (2) H3 K27M histone mutations, and (3) higher leptomeningeal dissemination.

Keyphrases

high grade
newly diagnosed
low grade
dna methylation
open label
randomized controlled trial
brain injury
young adults
study protocol