Dual molecule targeting HDAC6 leads to intratumoral CD4+ cytotoxic lymphocytes recruitment through MHC-II upregulation on lung cancer cells.
Sarah DucellierMélanie DemeulesBoris LetribotMassimiliano GaetaniChloé MichaudelHarry SokolAbdallah HamzeMouad AlamiMégane NascimentoSebastien ApcherPublished in: Journal for immunotherapy of cancer (2024)
cytotoxic T cell-mediated antitumor response in vivo in our model of lung cancer. This breakthrough suggests the potential of QAPHA as a promising agent for cancer treatment.