Sex-Related Effects of Adrenergic Drugs on Conditioned Pain Modulation: A Randomized Controlled Cross-Over Double-Blind Trial.
Marie-Philippe HarveyMarie-Chantal DuboisPhilippe ChalayeYanick SansoucySerge MarchandPublished in: Pain research & management (2022)
Increasing sympathetic activity with adrenergic agonists, such as ephedrine, could improve CPM effectiveness in women. It will be interesting to verify if the same results are present in patients suffering from chronic pain and if adrenergic agonists could have better therapeutic effects in women showing reduced CPM effectiveness.
Keyphrases
- chronic pain
- randomized controlled trial
- end stage renal disease
- polycystic ovary syndrome
- systematic review
- clinical trial
- pain management
- study protocol
- ejection fraction
- newly diagnosed
- phase iii
- chronic kidney disease
- double blind
- pregnancy outcomes
- peritoneal dialysis
- type diabetes
- pregnant women
- patient reported outcomes
- spinal cord
- neuropathic pain
- skeletal muscle
- open label