Macrolide Treatment Inhibits Pseudomonas aeruginosa Quorum Sensing in Non-Cystic Fibrosis Bronchiectasis. An Analysis from the Bronchiectasis and Low-Dose Erythromycin Study Trial.

Lucy D BurrGeraint B RogersAlice C-H ChenBrett R HamiltonGertruida F PoolSteven L TaylorDeon VenterSimon D BowlerSally BigaMichael A McGuckin

Published in: Annals of the American Thoracic Society (2017)

We demonstrate inhibition of P. aeruginosa quorum sensing within the airways of patients with non-cystic fibrosis bronchiectasis receiving long-term, low-dose erythromycin, without a reduction in bacterial load, representing a potential mechanism of therapeutic impact beyond a classical antimicrobial or antiinflammatory pathway.

Keyphrases

cystic fibrosis
low dose
pseudomonas aeruginosa
lung function
high dose
biofilm formation
staphylococcus aureus
acinetobacter baumannii
study protocol
phase iii
randomized controlled trial
combination therapy
phase ii
escherichia coli
climate change
replacement therapy
double blind
placebo controlled