Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages.
Patrick SüßMartin DieboldRoman SankowskiPublished in: Clinical and translational medicine (2024)
A recent study outlines the phenotypes of brain border region macrophages in developing, normal and glioblastoma-affected brains. For the first time, the authors show in-vivo turnover of human brain border macrophages. The findings have implications for the understanding of brain border immunity and potential macrophage targeting therapies. KEYPOINTS: Human border region macrophages are distinct from microglia. These distinct phenotypes are established early during embryonal development - Brain border macrophages are partially replaced by bone marrow-derived myeloid cells. The transcriptional phenotypes of glioblastoma-associated macrophage are determined by the anatomical region.
Keyphrases
- resting state
- white matter
- functional connectivity
- cerebral ischemia
- adipose tissue
- endothelial cells
- induced apoptosis
- oxidative stress
- brain injury
- inflammatory response
- signaling pathway
- climate change
- spinal cord
- body composition
- neuropathic pain
- subarachnoid hemorrhage
- cell death
- pluripotent stem cells
- cone beam computed tomography
- heat shock protein