First evaluation of PET-based human biodistribution and radiation dosimetry of 11C-BU99008, a tracer for imaging the imidazoline2 binding site.

Ashwin V VenkataramanNicholas KeatJames F MyersSamuel TurtonInge MickRoger N GunnEugenii A RabinerJan PasschierChristine A ParkerRobin J TyackeDavid J Nutt

Published in: EJNMMI research (2018)

The biodistribution of 11C-BU99008 has been shown here for the first time in humans. Our dosimetry data showed the total mean effective dose over all subjects was 0.0056 ± 0.0004 mSv/MBq, which would result in a total effective dose of 1.96 mSv for a typical injection of 350 MBq of 11C-BU99008. The effective dose is not appreciably different from those obtained with other 11C tracers.

Keyphrases

pet imaging
endothelial cells
positron emission tomography
high resolution
computed tomography
electronic health record
big data
pet ct
radiation therapy
mass spectrometry
ultrasound guided
pluripotent stem cells