First evaluation of PET-based human biodistribution and radiation dosimetry of 11C-BU99008, a tracer for imaging the imidazoline2 binding site.
Ashwin V VenkataramanNicholas KeatJames F MyersSamuel TurtonInge MickRoger N GunnEugenii A RabinerJan PasschierChristine A ParkerRobin J TyackeDavid J NuttPublished in: EJNMMI research (2018)
The biodistribution of 11C-BU99008 has been shown here for the first time in humans. Our dosimetry data showed the total mean effective dose over all subjects was 0.0056 ± 0.0004 mSv/MBq, which would result in a total effective dose of 1.96 mSv for a typical injection of 350 MBq of 11C-BU99008. The effective dose is not appreciably different from those obtained with other 11C tracers.