Procalcitonin-Guided Antibiotic Therapy Reduces Antibiotic Use for Lower Respiratory Tract Infections in a United States Medical Center: Results of a Clinical Trial.
Jennifer L TownsendVictoria AdamsPanagis GaliatsatosDavid PearseHardin PantleMary MastersonFlora KisuuleElsen JacobCatherine KiruthiPaul OrtizAlbert AgbanlogRobert JuraoSam SternSeema NayakMichael MelgarJacob SamaJillian IrwinCyrus MazidiKevin PsoterRobin McKenziePublished in: Open forum infectious diseases (2018)
A PCT-guided algorithm safely reduced the duration of antibiotics for treating LRTI. Utilization of a PCT algorithm may aid antibiotic stewardship efforts.This clinical trial was a single-center, controlled, pre-post study of PCT-guided antibiotic therapy for LRTI. The intervention (incorporation of PCT-guided algorithms) started on April 1, 2017: the preintervention (control group) comprised patients admitted from November 1, 2016 to April 16, 2017, and the postintervention group comprised patients admitted from April 17, 2017 to November 29, 2017 (Supplementary Figure 1). The study comprised patients admitted to the internal medicine services to a medical ward, the Medical Intensive Care Unit (MICU), the Cardiac Intensive Care Unit (CICU), or the Progressive Care Unit (PCU) "step down unit". The registration data for the trails are in the ClinicalTrials.gov database, number NCT0310910.
Keyphrases
- intensive care unit
- clinical trial
- healthcare
- machine learning
- deep learning
- randomized controlled trial
- primary care
- multiple sclerosis
- open label
- palliative care
- heart failure
- phase ii
- emergency department
- mechanical ventilation
- pain management
- bone marrow
- study protocol
- chronic pain
- acute respiratory distress syndrome
- adverse drug
- neural network