Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults.
Andrea R ZammitLei YuVladislav A PetyukJulie A SchneiderPhilip Lawrence De JagerHans-Ulrich KleinDavid A BennettAron S BuchmanPublished in: Neurology (2022)
Cortical proteins may provide some degree of cognitive resilience. These multifunctional proteins also seem to provide resilience to other AD clinical phenotypes and have independent associations with ADRD pathologies. Resilience proteins may be high-value therapeutic targets for drug discovery of interventions that maintain brain health in aging adults via multiple pathways.