Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles.
Gitishree DasHan-Seung ShinJayanta Kumar PatraPublished in: International journal of nanomedicine (2020)
The biosynthesis of the three generated Ag nanoparticles was confirmed through UV-vis spectrum analysis while the X-ray diffraction outlines revealed the generated AgNPs nature. The morphological structure and elemental information of the three AgNPs were obtained through SEM (scanning electron microscopy) and EDX (energy-dispersive X-ray) study. Multiple biological assays exhibited that the three generated AgNPs have significant cytotoxic, antidiabetic, and moderate antioxidant activity. In a comparative analysis, the PAP-AgNPs displayed higher anticancer potential than BVP and AHS-AgNPs, whereas AHS-AgNPs exhibited a higher antidiabetic effect with the lowest IC50 value (1.68 µg/mL) than PAP and BVP AgNPs. All three generated AgNPs displayed moderate antioxidant effects, among them BVP-AgNPs were more effective than PAP and AHS AgNPs. More than two effects of the three biosynthesized AgNPs specifies that they have ample perspective in therapeutic applications in pharmaceutical and other related industries in controlling cancer and diabetes.
Keyphrases
- silver nanoparticles
- electron microscopy
- high resolution
- oxidative stress
- cardiovascular disease
- magnetic resonance imaging
- squamous cell carcinoma
- healthcare
- computed tomography
- anti inflammatory
- high intensity
- metabolic syndrome
- young adults
- ionic liquid
- climate change
- social media
- lymph node metastasis
- data analysis
- aqueous solution