Human Intestinal Macrophages Are Involved in the Pathology of Both Ulcerative Colitis and Crohn Disease.
Suranga DharmasiriEva Maria Garrido-MartinRichard J HarrisAdrian C BatemanJane E CollinsJ R Fraser CummingsTilman Sanchez-ElsnerPublished in: Inflammatory bowel diseases (2022)
Our data support the therapeutic targeting of macrophages to maintain remission in IBD but also indicate that a shift toward an M2 program-as proposed by some reports-may not limit the recruitment and activation of T cells because M2 features do not preclude M1 activation in patients with UC or CD and could exacerbate M2-related CD-specific features such as fibrosis and the formation of granulomas.