Zinc and Insulin Resistance: Biochemical and Molecular Aspects.
Kyria Jayanne Clímaco CruzAna Raquel Soares de OliveiraJennifer Beatriz Silva MoraisJuliana Soares SeveroPriscyla Maria Vieira MendesStéfany Rodrigues de Sousa MeloGustavo Santos de SousaKyria Jayanne Clímaco CruzPublished in: Biological trace element research (2018)
Studies have shown the participation of minerals in mechanisms involved in the pathogenesis of insulin resistance. Zinc, in particular, seems to play an important role in the secretion and action of this hormone. Therefore, the aim of this review is to understand the role of zinc in increasing insulin sensitivity. We conducted a search of articles published in the PubMed and ScienceDirect database selected from March 2016 to February 2018, using the keywords "zinc," "insulin," "insulin resistance," "insulin sensitivity," and "supplementation." Following the eligibility criteria were selected 53 articles. The scientific evidences presented in this review show the importance of zinc and their carrier proteins in the synthesis and secretion of insulin, as well as in the signaling pathway of action of this hormone. Zinc deficiency is associated with glucose intolerance and insulin resistance; however, the effectiveness of the intervention with the zinc supplementation is still inconclusive.
Keyphrases
- insulin resistance
- oxide nanoparticles
- type diabetes
- adipose tissue
- randomized controlled trial
- metabolic syndrome
- high fat diet
- signaling pathway
- polycystic ovary syndrome
- glycemic control
- skeletal muscle
- systematic review
- blood pressure
- emergency department
- physical activity
- high fat diet induced
- epithelial mesenchymal transition
- cell proliferation
- induced apoptosis
- endoplasmic reticulum stress