Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.

Javier Arranz-NicolásMiguel Martin-SalgadoCristina Rodríguez-RodríguezRosa LiébanaMaria C Moreno-OrtizJudith LeitnerPeter SteinbergerAntonia Ávila-FloresIsabel Merida

Published in: Journal for immunotherapy of cancer (2021)

Our results, which define a role for DGKζ in the control of PD-1 expression, confirm DGKζ potential as a therapeutic target as well as a biomarker of CD8+ T cell dysfunctional states.

Keyphrases

poor prognosis
long non coding rna
protein kinase
human health