Ablation of Tacr2 in mice leads to gastric emptying disturbance.

Y-L MaoC-L ShenT ZhouB-T MaL-Y TangW-T WuH-X ZhangH-L LuW-X XuZhu-Gang Wang

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)

Tacr2 negatively regulated the expression of nNOS and VIP both in vivo and in vitro. Its ablation in mice elevated the expression of nNOS and VIP, enhanced NO signaling and changed the Creb and NF-κB signalings, finally leading to the gastric emptying disturbance of Tacr2-/- mice.

Keyphrases

high fat diet induced
poor prognosis
signaling pathway
oxidative stress
insulin resistance
binding protein
radiofrequency ablation
metabolic syndrome
type diabetes
adipose tissue
long non coding rna
atrial fibrillation
immune response
skeletal muscle
catheter ablation