Collagenase to facilitate guidewire crossing in chronic total occlusion PCI-The Total Occlusion Study in Coronary Arteries-5 (TOSCA-5) trial.
John J GrahamAkshay BagaiHarindra WijeysunderaGiora WeiszStéphane RinfretAlexander DickSanjit S JollyErick SchaempertSamer MansourVladimir DzavikJosé P S HenriquesBasem ElbarouniMinh N VoPatrick TeefyDavid GoodhartG B John ManciniBradley H StraussChristopher E BullerPublished in: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2022)
Local delivery of MZ-004 into coronary CTOs appears safe and may facilitate CTO crossing, particularly with softer tipped guidewires. These data support the development of a pivotal trial to further evaluate this agent.
Keyphrases
- coronary artery disease
- coronary artery
- phase iii
- study protocol
- phase ii
- clinical trial
- percutaneous coronary intervention
- acute myocardial infarction
- electronic health record
- randomized controlled trial
- coronary artery bypass grafting
- aortic stenosis
- open label
- heart failure
- big data
- atrial fibrillation
- machine learning
- st segment elevation myocardial infarction
- transcatheter aortic valve replacement
- placebo controlled