Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.
Basel MusmarHamza Adel SalimJihad AbdelgadirSamantha E SpellicyNimer AdeebAli ZomorodiAllan FriedmanIssam A AwadPascal M JabbourDavid M HasanPublished in: Journal of the American Heart Association (2024)
Our study explores the potential benefits of antithrombotic therapy in cerebral cavernous malformations. Although the analysis suggests a possible role for antithrombotic agents, it is critical to note that the evidence remains preliminary. Fundamental biases in study design, such as ascertainment and assignment bias, limit the weight of our conclusions. Therefore, our findings should be considered hypothesis-generating and not definitive for clinical practice change.
Keyphrases
- systematic review
- atrial fibrillation
- meta analyses
- clinical practice
- subarachnoid hemorrhage
- case control
- physical activity
- body mass index
- weight loss
- randomized controlled trial
- squamous cell carcinoma
- weight gain
- brain injury
- radiation therapy
- risk assessment
- mesenchymal stem cells
- cerebral blood flow
- blood brain barrier
- human health
- cell therapy
- smoking cessation