Effect of sildenafil on maternal hemodynamics in pregnancies complicated by severe early-onset fetal growth restriction: planned subgroup analysis from a multicenter randomized placebo-controlled double-blind trial.
Asma KhalilA SharpC CornforthR JacksonH MousaS StockJ HarroldM A TurnerL C KennyP N BakerEdward D JohnstoneP Von DadelszenL MageeAris T PapageorghiouZ AlfirevicPublished in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2021)
Sildenafil in a dose of 25 mg three times daily increases HR, reduces BP and reduces arterial stiffness in pregnancies complicated by severe early-onset FGR. These changes are short term, modest and consistent with the anticipated vasodilatory effect. They have no short- or long-term clinical impact on the mother. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Keyphrases
- early onset
- double blind
- placebo controlled
- phase iii
- phase ii
- clinical trial
- late onset
- study protocol
- pregnancy outcomes
- pulmonary hypertension
- preterm birth
- pulmonary arterial hypertension
- gestational age
- open label
- phase ii study
- birth weight
- blood pressure
- pregnant women
- randomized controlled trial
- systematic review
- radiation therapy
- squamous cell carcinoma
- rectal cancer
- body mass index