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Orai-vascular endothelial-cadherin signaling complex regulates high-glucose exposure-induced increased permeability of mouse aortic endothelial cells.

Yuan WeiSuwen BaiYanHeng YaoWenxuan HouJunwei ZhuHaoshu FangYinan DuWei HeBing ShenJuan Du
Published in: BMJ open diabetes research & care (2021)
HG exposure stimulated increased expression of Orais in endothelial cells, and increased VE-cadherin phosphorylation through Orais-VE-cadherin complex and a series of downstream signaling pathways, resulting in disruption of endothelial cell junctions and initiation of atherosclerosis.
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