Modulation of Breast Cancer Cell FASN Expression by Obesity-Related Systemic Factors.
Bryan McClellanTommy PhamBrittany HarlowGabby LeeDuan QuachChristopher JollyAndrew BrennerLinda deGraffenriedPublished in: Breast cancer : basic and clinical research (2022)
Our results implicate FASN as a potential mediator of obesity-induced breast cancer aggression and a therapeutic target of patients with obesity-induced breast cancer.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- high glucose
- diabetic rats
- drug induced
- poor prognosis
- adipose tissue
- stem cells
- single cell
- endothelial cells
- body mass index
- physical activity
- young adults
- oxidative stress
- binding protein
- risk assessment
- long non coding rna
- breast cancer risk
- human health
- stress induced