COMP-angiopoietin-1 ameliorates inflammation-induced lymphangiogenesis in dextran sulfate sodium (DSS)-induced colitis model.

Ae Sin LeeMi Jeong SungWon KimYu Jin Jung

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

COMP-Ang1 decreases inflammatory-induced lymphangiogenesis in experimental acute colitis. COMP-Ang1 improves the symptom of DSS-induced inflammatory response. COMP-Ang1 reduces the expression of pro-inflammatory cytokines in inflamed colon. COMP-Ang1 reduces the expression of VEGFs in inflamed colon. COMP-Ang1 prevents infiltration of macrophages in a DSS-induced colitis model.

Keyphrases

angiotensin ii
high glucose
inflammatory response
diabetic rats
drug induced
poor prognosis
oxidative stress
mouse model
binding protein
intensive care unit
hepatitis b virus