Overexpression of miR-17-5p may negatively impact p300/CBP factor-associated inflammation in a hypercholesterolemic advanced prostate cancer model.

Ruan C P PimentaJuliana A CamargoGuilherme L GonçalvesVitória GhazarianPatrícia CandidoVanessa R GuimarãesPoliana RomãoCaroline ChiovattoKarina Serafim da SilvaGabriel A Dos SantosIran A SilvaWilliam C NahasKátia R LeiteAna Flávia Marçal PessoaNayara I VianaSabrina T Reis

Published in: Molecular biology reports (2023)

Our results demonstrate that inducing miR-17-5p expression suppresses tumor growth and inflammatory mediator expression. Further studies should be conducted to fully explore the role of miR-17-5p and the involvement of inflammatory mediators p300, PCAF, and IL-6.

Keyphrases

prostate cancer
poor prognosis
oxidative stress
radical prostatectomy
cell proliferation
binding protein
signaling pathway
transcription factor